Cholera and Spatial Epidemiology
نویسندگان
چکیده
Cholera is an acute intestinal infection caused by the water borne bacteria Vibrio cholerae O1 or O139 (V. cholerae). Infection is mainly through ingestion of contaminated water or food (Kelly, 2001). Approximately 102-103 cells are required to cause severe diarrhea and dehydration (Sack et al., 1998; Hornich et al., 1971). Ingested cholera vibrios from contaminated water or food must pass through the acid stomach before they are able to colonize the upper part of the small intestine. After penetrating the mucus layer, V. cholerae colonizes the epithelial lining of the gut, secreting cholera toxin which affects the small intestine.
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